GENE TRANSCRIPTION

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A: Overview of Gene Expression

B: Overview of Transcription

• RNA Polymerases

C: Gene's Regulatory Elements

• Promoter
• The lac Operon Promoter
• The IL-2 Promoter
• Enhancer
• Silencer
• Response Elements

D: Transcription Mechanisms in Prokaryotes

• Transcriptional Termination in Prokaryotes
• Regulation of lac Operon Transcription
• Activation of glnA Transcription by NTRC

E: Transcription Mechanisms in Eukaryotes

• Assembly of the Pre-Initiation Complex

F: Motif Structures of Transcription Factors

• Zinc Finger
• Helix-Turn-Helix
• Leucine Zipper
• Helix-Loop-Helix

G: Histone Acetylation and DNA Methylation

• CREB Binding Protein (CBP) and p300
• Transcriptional Regulation by Histone Acetylation and Deacetylation

H: Regulation of Transcription Factors

• Regulation of lac Repressor
• Regulation of l Repressor (cI)
• Regulation of NF-kB
• p53

I: Transcription of RNA Genes

J: Genomic Replications of Viruses

• Mechanism of Reverse Transcription
• Generation of Retroviral Genomic RNA